Table 3. Proliferation Inhibitory Activities of Selected SOS1 Inhibitors in MIA PaCa-2 Cells.

compound	IC50 (nM)a
8e	160 ± 37
8f	190 ± 20
8h	92.0 ± 29.9
8i	74.8 ± 19.3
8j	429 ± 156
8p	156 ± 37
8q	459 ± 86
8u	27.7 ± 5.7
8v	90.1 ± 22.3
8w	340 ± 57
8x	317 ± 87
BI-3406	30.0 ± 4.6

^aIC₅₀ values are shown as the mean ± SD from four replicate experiments.