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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: J Allergy Clin Immunol Pract. 2022 Sep 23;10(12):3117–3123. doi: 10.1016/j.jaip.2022.09.022

Figure 1:

Figure 1:

Schematic of hypothesis of mechanistic link between early life PPI exposure and risk of subsequent atopy. In susceptible individuals, prenatal or early life PPI exposure reduces gastric acid. While this mechanism is not fully understood, microbial dysbiosis and later atopic disease may occur in a subset of patients. Figure created with biorender.com.