Table 1.

SEP-1 guidelines for sepsis treatment.

Diagnosis	Within 3 h	Within 6 h
Severe Sepsis (ICD-10 R65.2)	Lactate Blood culture before antibiotics Antibiotics administration 30 mL/kg IVF (if hypotensive)	Repeat lactate Perform a volume status or perfusion exam
Septic Shock (ICD-10 R65.21)	Lactate Blood culture before antibiotics Antibiotics administration 30 mL/kg IVF	Repeat lactate Vasopressors (if systolic blood pressure <90 after 30 mL/kg IVF) Perform a volume status or perfusion exam

ICD: International Classification of Diseases; IVF: Intravenous fluids; SEP-1: The severe sepsis and septic shock management bundle.