TABLE IV.
Endogenous (host-originated) and endobiotic (symbiont-originated) CD1d ligands
| Name | Representative Chemical Structure |
Category | Class | Activity | Reference |
|---|---|---|---|---|---|
| 3′-Sulfo-galactosyl ceramide (“sulfatide”) |
|
Endogenous ligand | β-Anomeric sulfatide | Type II NKT agonist | (38) |
| PI |
|
Endogenous ligand | Glycerophospholipid | Agonist for specific NKT cell subset | (99) |
| p-LysoPE |
|
Endogenous ligand | Lysophospholipid (ether-linked) | Agonist for thymic/peripheral NKT cells | (100) |
| iGb3 |
|
Endogenous ligand | Isogloboside | Weak agonist | (101) |
| BfaGC (shown as SB2217) |
|
Endobiotic ligand (symbiotic B. fragilis) | α-GalCer | Immunomodulatory | (102) |
iGb3, isoglobotrihexosylceramide; PI, phosphatidylinositol.