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. 2023 Feb 9;66(4):2663–2680. doi: 10.1021/acs.jmedchem.2c01627

Figure 6.

Figure 6

Alkynes are important functional groups in human therapeutics. (a) Representative human therapeutics that contain alkynes (in green); (b) covalent reaction of acalabrutinib (36)87 with Btk Cys481.