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Reagents and conditions: (a) LiOH, THF/H2O, 0 °C to room temperature (rt), 83%; (b) Me(OMe)NH·HCl, 1,1′-carbonyldiimidazole (CDI), iPr2NEt, CH2Cl2, rt, 58%; (c) LiAlH4, THF/Et2O, −78 °C, 93%; (d) 10,59,60 K2CO3, MeOH, rt, 43%; (e) HCl (4 M in dioxane), CH2Cl2, rt, app. quant.; (f) 12,1 COMU,55N-methylmorpholine (NMM), DMF/CH2Cl2, 0 °C to rt, 17%.
