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. 2023 Feb 13;47(4):325–334. doi: 10.1038/s41366-023-01272-x

Fig. 2. STING inhibition alleviated lung inflammation in obese mice.

Fig. 2

a Body weight of DIO/C-176 (n = 13), DIO/vehicle (n = 11) and lean/vehicle (n = 11) mice groups during regular chow and high fat diet feeding with C-176 or vehicle treatment. b, c Representative western blots of STING (b) and group data of STING (c) fold change in equal amounts of protein extracts of mice lung tissues (n = 5–7 each group). d qPCR analysis showed the mRNA levels of TNF-α, IL-6 and IFNβ in mice lung tissues (n = 5–7 each group). e ELISA analysis showed that the protein levels of proinflammatory cytokines, including IL-6, TNF-α, and IFNβ, in lung homogenates (n = 5–7 each group). f ELISA analysis showed the levels of proinflammatory cytokines in mouse BALFs (n = 6 each group). g Representative H&E images of the lungs in the lean and DIO mice with C-176 or vehicle treatment (n = 3 each group). Data represent mean ± SD. ###P < 0.001, lean + vehicle group vs. DIO + vehicle group. ***p < 0.001, lean + vehicle group vs. DIO + vehicle group, DIO + vehicle group vs. DIO + C-176 group. Statistical significance was determined by one-way ANOVA followed by post-hoc LSD-t or Games-Howell method. Scale bars, 100 μm.