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. Author manuscript; available in PMC: 2023 Jul 11.
Published in final edited form as: Nat Cell Biol. 2022 Jul 11;24(7):1154–1164. doi: 10.1038/s41556-022-00950-8

Extended Data Fig. 2: Increased innate immune signaling in Abro1-deficient cells depends on DNA2 but not MRE11.

Extended Data Fig. 2:

(a) Inhibition of Mre11 does not decrease pSTAT levels in Abro1 KO cells. Cells were treated with 4 mM HU in the absence or presence of Mirin. (b) Inhibition of Mre11 does not decrease cytosolic ssDNA in Abro1 KO cells. Immunofluorescence was performed with ssDNA antibody. Scale bars, 10 μm. Quantification of cytosolic ssDNA (mean fluorescence intensity, MFI) is shown with mean ± SD. One way Anova was used for statistics. ‘n’ refers the number of cells analysed across three independent experiments. (c) Knockdown of RAD51 decreases pSTAT1 levels in Abro1 KO cells. Cells were treated with 4 mM HU. Data shown represent three independent experiments in a and c.