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. Author manuscript; available in PMC: 2024 Feb 25.
Published in final edited form as: Int J Pharm. 2023 Jan 16;633:122613. doi: 10.1016/j.ijpharm.2023.122613

Figure 6.

Figure 6.

Concentration - time curves and calculated pharmacokinetic parameters of nanocrystal dispersion (NC) and lipid nanoparticles (LNP) in plasma (a) and brain (b) after oral administration (dose 8 mg/kg) in rats (n = 3 per time point) (Cmax - maximum concentration, tmax - time of maximum concentration, t1/2 - terminal elimination half-life, AUC0-24(36) area under the concentration versus time curve). Due to erratic concentration-time profiles, the terminal elimination half-life in brain was not calculated.