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Pharmacokinetic parameters after oral gavage of LNP and NC formulation and intravenous SOL administration (n=4 rats per group, results are expressed as mean ± SD).
| Cmax (ng/ml) | Tmax (h) | AUC0–24 (ng·h/ml) | t1/2 (h) | F (%) | |
|---|---|---|---|---|---|
|
| |||||
| LNP | 1345.35 ± 357.86 | 3.13 ± 2.39 | 14164.44 ± 5462.42 | 17.29 ± 19.01 | 34.71 ± 12.43 |
| NC | 1018.19 ± 546.88 | 2.81 ± 2.67 | 11775.82 ± 6443.16 | 10.47 ± 9.45 | 24.46 ± 7.81 |
| SOL | 5197.97 ± 2043.49 | 0.12± 0.08 | 45790.81 ± 11459.86 | 3.76 ± 1.77 | |
