FIGURE 2.

A novel epigenetic clock for adult chondrocytes. (a) Epigenetic clock for adult chondrocytes shows high correlation between epigenetic age and chronological age. (b,c) Administration of a small molecule STAT3 agonist to adult chondrocytes for 2 weeks lowers epigenetic age. (d) Differentially methylated CpGs in 2 weeks cultured treated chondrocytes compared to control samples show global gain in hypomethylation (e) Gene ontology enrichment analysis for the genes‐associated with differentially hypomethylated CpGs. DMPs, differentially methylated CpG probes