FIGURE 2.

Resistance to multiple types of stress is significantly correlated with longevity. To determine the extent to which each type of stress resistance is correlated with lifespan, we compared the magnitude of lifespan extension to the percentage or duration of survival following exposure to exogenous stressors. There is a significant correlation with each of the six different types of stress resistance and lifespan including heat stress (a), chronic oxidative stress (b), acute oxidative stress (c), bacterial pathogens (d), osmotic stress (e), and anoxia (f). The highest degree of correlation was observed for bacterial pathogen stress. Combining all six types of stress resistance together into a combined survival score only slightly increased the degree of correlation with lifespan (g). The highest correlation with lifespan was achieved by using the number of stresses that a particular mutant is resistant to (h). Note that in panels b and d average survival was graphed as these stress assays were monitored until completion, while the other panels examine a specific time point. *p < .05, **p < .01, ***p < .001.