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. 2023 Feb 13;18(2):e0281610. doi: 10.1371/journal.pone.0281610

Fig 8. Proposed model for KDM4D and Hippo signaling pathway in the regulation of cell cycle activities.

Fig 8

KDM4D preferentially induced expression of genes regulating late (G2/M) phases of the cell cycle by stimulating E2F1 and FoxM1 expression, while miR-199 or Hippo pathway inhibition preferentially up-regulated genes involved in G1/S phase by stimulating Myc expression.