Figure 4. Apical periodontitis (AP) suppressed transcriptionally inferred cellular interactions and increased a self-supporting network within the mesenchymal stem cell (MSC) cluster.

(A–C) Network plot of ligand-receptor activity in control (A), AP (B), and AP versus control (C). (D) Bar plot of top 10 most abundant ligands in all inferred ligand-receptor interactions. (E) Ranking of ligand/source regarding communication gains in AP state. (F and G) Sankey plot listing all predicted source, receptor, and receiver interactions associated with Fn1 and Sele.