Table 8. Maximum DAIDS QTc* Grade of Visit or change from baseline.
| DAIDS GRADE QTc* | 1200mg FZC n = 22 | 1600mg FCZ n = 50 | 2000mg FCZ n = 48 | AMB n = 48 | TOTAL n = 168 |
|---|---|---|---|---|---|
| 1. normal | 5 (23%) | 16 (32%) | 14 (29%) | 12 (25%) | 47 (28%) |
| 2. mild | 7 (32%) | 18 (36%) | 13 (27%) | 20 (42%) | 58 (35%) |
| 3. moderate | 5 (23%) | 11 (22%) | 14 (29%) | 10 (21%) | 40 (24%) |
| 4. severe | 5 (23%) | 5 (10%) | 7 (15%) | 6 (12.5%) | 23 (14%) |
*QTc calculated using the Frederica equation.
Note: A change from baseline can result in a graded QTc while the QTc result at the visit is still in the normal range. There was no significant difference between groups using the Kruskall Wallis test.