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Linaclotide does not induce a change in short-circuit current (Isc) in F508del intestinal tissue. A: representative Isc tracings from two wild-type (WT) and F508del duodenums treated with 10 µM linaclotide (indicated by ↓). B: average change in Isc measurements from the duodenum and ileum of WT and F508del mice. (Isc was averaged from a minimum of 4 mice per group ± SE; *P < 0.05.)
