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Linaclotide treatment improves gastrointestinal transit in F508del and Cftr null mice. Adult wild-type (WT), null, and F508del mice were treated with either 50 µg/kg linaclotide or vehicle control. (Bars represent means ± SE; *P < 0.01 vs. WT, ^P < 0.05 vs. vehicle group of the same genotype, n ≥ 7.)
