Fig. 1.

Incidence of cardiovascular disease (CVD) according to low-density lipoprotein cholesterol (LDL-C) levels in total subjects with diabetes mellitus (A) and in those with comorbidities (B). Multivariable Cox proportional hazards regression analysis was performed by adjusting for age, sex, body mass index, hypertension (HT), current smoking, alcohol intake, regular physical activity, estimated glomerular filtration rate, triglyceride-lowering medication, and statin treatment. Risk factors: age (male ≥45 years, female ≥55 years), family history of CVD, HT (systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥90 mm Hg or taking antihypertensive drugs), current smoking, low high-density lipoprotein cholesterol (<40 mg/dL). HR, hazard ratio; CI, confidence interval. ^aP<0.001 compared with an LDL-C level of <70 mg/dL.