Figure 4.

Data visualization and exploration

(A) All quantifiable data points reflecting K_A (in M⁻¹) and IgG concentration values (in M) are plotted..

(B) Same as (A) but including a 2D scatter plot with integrated density contours. Triangles denote patients receiving the REGN-COV cocktail. RBD variants: wild type (WT, gray), delta (blue), omicron (yellow). Dotted lines represent the measurements of the same patient sample against different RBD variants. Plot taken from.¹ Higher affinity and higher concentration (for A and B) are indicated in red writing with an arrow. 95% confidence intervals for each point are colored in light red.

(C) Boxplot analysis of K_A values for WT, delta, and omicron RBD variants. Samples of patients treated with REGN-COV antibody cocktail are shown in red color.

(D) K_A and IgG concentration were plotted against the respective ELISA titers, i.e., p(EC₅₀) values, obtained for WT, delta, and omicron RBD variants. Concentration, but not affinity, is shown to correlate with titers measured by ELISA. Data and plots are from work recently published.¹