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. 2023 Jan 6;324(3):H330–H337. doi: 10.1152/ajpheart.00708.2022

Figure 1.

Figure 1.

Baseline microvascular function over time and with preexisting disease in untreated arterioles from females and males. A: response to flow in arterioles from females <40 (n = 22), 40–55 (n = 24), and >55 (n = 11) yr of age. B: maximal dilation to 100 µM papaverine in arterioles from females <40 (n = 21), 40–55 (n = 20), and >55 (n = 9) yr of age (P = 0.738). C: flow response curves in arterioles from non-CAD (n = 57; 30–78 yr) and CAD (n = 6; 53–79 yr of age) females. D: FID in arterioles from non-CAD males (n = 24; 35–74 yr of age) and females (n = 57; 30–78 yr). E: response to flow in arterioles from females (n = 6; 53–79 yr) and males with CAD (49–78 yr). F: sex differences in maximal dilation to 100 µM papaverine in arterioles from non-CAD (male, n = 49; female, n = 19; P = 0.890) vs. CAD patients (female, n = 6; male, n = 19; P = 0.078). Response to flow in arterioles from non-CAD females <40 (n = 22; G), 40–55 (n = 24; H), and >55 (n = 11; I) yr of age, with or without Nω-nitro-l-arginine methyl ester (l-NAME; 100 µM, 30 min) (<40 yr, n = 16; 40–55 yr, n = 15; >55 yr, n = 14) or PEG-catalase (<40 yr, n = 11; 40–55 yr, n = 13; >55 yr, n = 10). Comparison of area under the l-NAME (J) and PEG-catalase (K) curves for women across age groups. L: response to flow in arterioles from females with CAD with or without l-NAME or PEG-catalase (n = 8 each). Effect of pressure gradient alone was <0.05 in all groups. *P < 0.05: two-way ANOVA treatment effects (A, C–E, G–I, and L) and one-way ANOVA with Fisher’s least significant difference (LSD) test (B and F). CAD, coronary artery disease; FID, flow-induced dilation.