Table 3.
Clinical trials of MSC-EVs in periodontitis and other diseases
| Disease | MSC type | Country | NCT number | Status |
|---|---|---|---|---|
| Oral diseases | ||||
| Periodontitis | ADSCs | Egypt | NCT04270006 | Unknown |
| Trauma | ||||
| Burn wounds | BMSCs | Not shown | NCT05078385 | Not yet recruiting |
| Wound healing | ADSCs | China | NCT05475418 | Not yet recruiting |
| Gastrointestinal diseases | ||||
| Medically refractory Crohn's disease | Adult allogeneic BMSCs | Not shown | NCT05130983 | Not yet recruiting |
| Medically refractory ulcerative colitis | Adult allogeneic BMSCs | Not shown | NCT05176366 | Not yet recruiting |
| Resistant perianal fistula | Placental mesenchymal stem cell | Iran | NCT05499156 | Not yet recruiting |
| Complex anal fistula | Placental mesenchymal stem Cell | Iran | NCT05402748 | Recruiting |
| Neonatal-related diseases | ||||
| Preterm neonates at high risk of bonchopulmonary dysplasia | BMSCs | US | NCT03857841 | Terminated |
| Extremely low birth weight infants | MSCs | Russian | NCT05490173 | Not yet recruiting |
| Organ transplant | ||||
| Abdominal solid organ transplant | BMSCs | Not shown | NCT05215288 | Not yet recruiting |
| Autoimmune disease | ||||
| Dystrophic epidermolysis bullosa wounds | BMSCs | Not shown | NCT04173650 | Not yet recruiting |
| COVID-19 | ||||
| Mild-to-moderate COVID-19 | BMSCs | US | NCT05125562 | Not yet recruiting |
| COVID-19 Moderate-to-Severe ARDS | BMSCs | US | NCT05354141 | Recruiting |
| Post-acute COVID-19 and chronic post-COVID-19 syndrome | BMSCs | Not shown | NCT05116761 | Not yet recruiting |
| COVID-19-associated ARDS | BMSCs | US | NCT04493242 | Completed |