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. 2023 Feb 6;2023:6341011. doi: 10.1155/2023/6341011

Figure 6.

Figure 6

MALAT1 up-regulated STAT3 and activated PI3K/AKT pathway by adsorbing miR-370-3p to promote cisplatin resistance in CC cells. MALAT1 low expression plasmid and miR-370-3p inhibitors were co-transfected into Hela/R and C33A/R cells. (a) qRT-PCR was used to detect the level of STAT3. (b) The protein levels of phosphorylated PI3K (p-PI3K), total PI3K, phosphorylated AKT (p-AKT) and total AKT were detected by the Western blot method. Pretreatment of CC cisplatin-resistant cells with PI3K/AKT specific inhibitor LY294002. (c) CCK-8 assay was used to detect cell proliferation. (d) Apoptosis was detected by flow cytometry. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001. All experiments were performed at least three times.