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. 2023 Jan 10;13(3):873–895. doi: 10.7150/thno.77444

Figure 8.

Figure 8

Schematic model showing how NQO1 regulates cell cycle progression at the G2/M phase in cancer cells. Newly synthesized c-Fos is degraded by the 20S proteasome. NQO1 physically interacts with c-Fos to inhibit degradation by the 20S proteasome, after which c-Fos associates with c-Jun, forming an AP-1 complex that translocates to the nucleus and binds to the TRE of the CKS1B promoter to drive expression of the CKS1B gene. Upon translation, CKS1 protein regulates G2/M phase progression of the cell cycle.