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. 2023 Jan 16;13(3):931–954. doi: 10.7150/thno.78639

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pH-responsive biomaterials for OA treatment: (A) Schematic assembly procedure of CSL@HMSNs-Cs and mechanism of intra-articular injection of CSL@HMSNs-Cs serving as a pH-responsive medicine for anti-inflammatory therapy of osteoarthritis ⁸⁵. Copyright 2020, BMC. (B) TEM images of HMSN, CSL@HMSNs-CS and cumulative release curves of CSL@HMSNs-CS in different pH PBS ⁸⁵. Copyright 2020, BMC. (C) Schematic showing pH-responsive polymeric prodrug of curcumin as a therapeutic system for osteoarthritis ⁸⁴. Copyright 2019, Elsevier. (D) Fluorescence images and quantitative analysis of MIA joints injected with ACP micelles ⁸⁴. Copyright 2019, Elsevier.