Skip to main content
. 2023 Jan 22;13(3):1076–1090. doi: 10.7150/thno.79434

Figure 6.

Figure 6

FGF21 overexpression in Ptp4a1-/- mice decreases a high-fat (HF) diet-induced hyperglycemia and NAFLD. (A) The experimental design for administering adenovirus on HF diet-fed Ptp4a1-/- mice. (B) The levels of Fgf21 mRNA in the liver and FGF21 in plasma of Ptp4a1-/- mice administrated with Ad-Ctrl or Ad-Fgf21 after feeding an HF diet (n = 7). (C) Blood glucose levels (left) and plasma insulin levels (right) in Ptp4a1-/- mice administrated with Ad-Ctrl or Ad-Fgf21 after feeding an HF diet (n = 7). (D) The representative images for hematoxylin&eosin (H&E) staining and oil red O staining in the liver sections of Ptp4a1-/- mice administrated with Ad-Ctrl or Ad-Fgf21 after feeding an HF diet (n = 7). Scale bar, 200 μm. (E) Hepatic triglyceride (TG) levels in Ptp4a1-/- mice administrated with Ad-Ctrl or Ad-Fgf21 after feeding an HF diet (n = 7). Data are presented as the mean ± standard error of the mean. **P < 0.01 (two‐tailed Student's t‐test for B (left); Mann-Whitney U test for B (right), C, and E).