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. 2023 Jan 16;13(3):913–930. doi: 10.7150/thno.78777

Figure 4.

Figure 4

ELA diminishes the differentiation of OPCs into OLs and can be reversed by early PBM treatment. A (a-c) and B (a-c) Representative immunofluorescence staining for - OLs (Olig2+, red) - labeled PDGFRα+ (blue) in CA1 region of hippocampus. A (d) and B (d) Representative synthetic protein bands of PDGFRα in the hippocampus, corresponding peak areas were normalized with the level of total protein. A (e) The depicted area was imaged in the hippocampal CA1 region, graphical representation of the different oligodendrocyte lineage stages and respective markers used in this study. C (a, b) Results of quantitative analysis of PDGFRα protein levels. C (c, d) Percentage of Olig2+- labeled OPCs (Olig2+ PDGFRα+ cells) in the total PDGFRα+ cells. ELA-exposured rats exhibited a dramatic reduction in the differentiation of OPCs into OLs, which was reversed by early PBM treatment. Scale bar = 10 µm. All data are presented as mean ± SE (n = 5-7). * P < 0.05 versus Control-group; # P < 0.05 versus ELA-group.