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Graphical abstract. Repeated unpredictable electric foot shocks early in life lead to compromised antioxidant defenses and accumulation of ROS in the brain, which in turn causes oligodendrocyte oxidative damage and dysfunction as well as neurologic syndromes in adulthood. Conversely, early transcranial PBM treatment improves redox homeostasis in the brain, therefore helps maintain oligodendroglial homeostasis, resulting in better outcomes in animals.
