TABLE 2.

Clinical characteristics of patients with adrenal insufficiency

	Total
	n = 10
Clinical symptoms
General fatigue, n (%)	6 (60)
Loss of appetite, n (%)	6 (60)
Loss of body weight, n (%)	2 (20)
Central nervous systems, n (%)	3 (30)
Nausea, n (%)	1 (10)
Fever, n (%)	3 (30)
No symptoms, n (%)	1 (10)
Laboratory findings
Hyponatremia, n (%)	9 (90)
Hypoglycemia, n (%)	2 (20)
Eosinophilia, n (%)	4 (40)
Cycles (range)	7.5 (range 4–14)
Onset time (range), month	8.0 (3.8–15.2)
CTCAE grade (2/3/4), n (%)	1(10)/8(80)/1(10)
Serum ACTH
Low ACTH, n (%)	10 (100)
Pituitary deficiencies
Isolated ACTH deficiency, n (%)	5 (50)
ACTH and gonadotropic deficiency, n (%)	1 (10)
No hormonal dynamic test	4 (40)
Pituitary MRI
No abnormality, n (%)	8 (80)
No imaging, n (%)	2 (20)
Treatment
Corticosteroid replacement	10 (10)
Re‐administration of pembrolizumab
Yes	5 (50)
No	5 (50)

Note: Definitions: hyponatremia <135 mEq/L; hypoglycemia <65 mg/dl; eosinophilia >500/μL.

Abbreviations: ACTH, adrenocorticotropic hormone; CTCAE, common terminology criteria for adverse event v5.0; MRI, magnetic resonance imaging.