Skip to main content
. 2022 Dec 20;55(2):333–345. doi: 10.1038/s41588-022-01260-3

Fig. 5. TF motifs underlie active and repressive chromatin dynamics in hematopoiesis.

Fig. 5

a, Examples of four TF motifs whose activities are predicted to drive cell-type-specific H3K4me1 distributions. The ERG motif is predicted to be active in HSPCs, the CEBP motif in neutrophils, the EBF motif in B cells and the TAL1 motif in erythroblasts. Cell type for each cell cluster is labeled in b. b, Heatmap of H3K4me1 TF motif activities in single cells. Rows represent motifs. Columns are individual cells whose cell types are annotated by the top color bar. The right panel shows an H3K4me1 UMAP colored by cell types, with cell-type-to-color legend below. c. Predicted H3K27me3 activity of a motif belonging to the Yin Yang (YY) protein family in single cells. Circled cluster is enriched for HSPCs. d, Predicted H3K9me3 activity of PLZF motif in single cells. Circled cluster is enriched for HSPCs.