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. 2022 Dec 20;55(2):333–345. doi: 10.1038/s41588-022-01260-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Graphical summary of chromatin dynamics as dendrograms showing relationships between HSPCs and differentiated cells. During hematopoiesis, the direction of change in active chromatin depends on the specific cell fate, resulting in global differences that are larger between differentiated cell types from different lineages. By contrast, many regions gain or lose repressive marks during hematopoiesis independent of the specific cell fate, resulting in global differences that are the largest between HSPCs and differentiated cell types. Dynamics in active marks and H3K27me3-marked repressive chromatin reveal cell type information, while dynamics in heterochromatin regions marked by H3K9me3 reveal lineage information. CP, common progenitors.