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. 2023 Jan 26;55(2):246–254. doi: 10.1038/s41588-022-01296-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — Regression lines were estimated using linear mixed models. Error bands represent 95% confidence interval for the fixed effect of age. Colors indicate biopsy regions, with orange, green and blue representing duodenum, ileum and jejunum, respectively. Shapes indicate whether the donor has a celiac history or not. Crosses indicates donors with a celiac history, and dots indicate donors without a celiac history. (a) SBS1 burden versus age, showing regression lines for the three different sectors of the small intestine. (b) SBS5 burden versus age, showing a regression line for all samples because the rate is not statistically different for the three sectors according to linear mixed models. (c) SBS18 burden versus age, showing a regression line for all samples because the rate is not statistically different for the three sectors according to linear mixed models. (d) SBS2 burden versus age, the relationship is not linear. (e) SBS13 burden versus age, the relationship is not linear.