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. 2023 Jan 26;55(2):246–254. doi: 10.1038/s41588-022-01296-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — APOBEC-positive crypts and their surrounding crypts before microdissection with their SBS mutational spectrums. Signatures exposures are color coded on top left. Red dots, APOBEC-positive crypts. Blue dots, APOBEC-negative crypts that have been sequenced. Gray rectangles on the mutational spectra circle characteristic peaks of SBS2/SBS13. a, PD43401, this individual has one APOBEC-positive crypt but all the remaining crypts in the neighborhood are negative. b, PD52487, with an APOBEC-negative crypt (PD52487b_lo0005) between APOBEC-positive crypts. c, PD45778, an APOBEC-negative crypt (PD45778b_lo0002) between APOBEC-positive crypts.