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. 2023 Jan 26;55(2):246–254. doi: 10.1038/s41588-022-01296-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — Boxplot of SBS2/13 exposures in small bowel adenocarcinomas and normal crypts with APOBEC mutagenesis (n = 14 for adenocarcinomas and n = 58 for normal crypts). The central line, box and whiskers represent the median, interquartile range (IQR) from first to third quartiles, and 1.5 × IQR, respectively. Burdens in cancer WES data have been adjusted by the proportion of exomes in genome to compare with whole-genome sequencing data. Median = 1691 (adenocarcinoma) and 242 (normal), two-tailed t-test P = 2 × 10⁻⁴.