Fig. 4. Different brain tissues are enriched with distinct pathways.

We used REVIGO to reduce redundant GO terms and facilitate the visualization of enrichment results. We highlighted three brain regions (that is, cortex, substantia nigra and cerebellum) with distinct patterns of enrichment. For brain cortex, one GO term (relaxation of smooth muscle) accounts for 98.3% of the pathways enriched with TWAS hits, whereas, for substantia nigra and cerebellum, a diverse set of GO terms was enriched with TWAS hits. The brain figures are generated by R package ggseg⁴³.