Fig. 8.

ANXA1 (Ac2-26) protected renal function, survival and cell viability via Fpr2 in CLP-induced mice and LPS-induced HK-2 cells. A–D Renal function, survival rate and cell viability were detected by ELISA and CCK-8 after CLP or LPS (10 µg/ml) for 24 h. Note: LPS (10 μg/mL), Ac: ANXA1 (Ac2-26) (0.5 μmol/L); Con: control group; LPS: LPS group; LPS + Ac: LPS + Ac2-26 group; LPS + Ac + Frp2-siRNA: LPS + Ac2-26 + Fpr2-siRNA group. The data are represented as the mean ± SEM. The data were independently replicated in triplicate. *P < 0.05, **P < 0.01, ***P < 0.001