Table 3.

EORTC QLQ C30 at pre-radiotherapy, 1 and 5 years post-radiotherapy for patients with and without trismus (mean (95% CI))

	Pre-RT	1 year post-RT			5 years post-RT
	No trismus (n = 211)	Trismus (n = 49)	No trismus (n = 131)	P value	Trismus (n = 36)	No trismus (n = 93)	P value
	Mean (95% CI)	Mean (95% CI)	Mean (95% CI)		Mean (95% CI)	Mean (95% CI)
Functioning domains
Physical function	89.7 (87–92)	81.9 (77–87)	88.5 (86–91)	0.03	81.4 (74–89)	84.9 (81–89)	0.42
Role function	74.2 (70–79)	65.6 (56–75)	82.5 (78–87)	< 0.001	70.6 (59–82)	85.9 (81–91)	0.01
Emotional function	70.1 (67–73)	76.2 (69–84)	83.6 (80–87)	0.06	76.0 (67–85)	87.1 (83–91)	< 0.01
Cognitive function	85.0 (83–88)	81.3 (75–88)	86.4 (83–90)	0.14	74.5 (65–84)	87.1 (84–90)	< 0.01
Social function	82.9 (80–86)	71.8 (63–81)	84.0 (80–88)	< 0.01	73.0 (63–83)	87.4 (83–92)	< 0.01
Global quality of life	65.8 (63–69)	62.8 (56–70)	71.3 (68–75)	0.02	61.0 (51–71)	75.5 (71–80)	< 0.01
Symptom scales
Fatigue	23.0 (20–26)	32.2 (25–40)	23.8 (20–28)	0.04	36.6 (23–50)	20.5 (16–26)	< 0.01
Nausea/vomiting	4.6 (3–6)	6.8 (3–11)	3.6 (2–6)	0.14	8.8 (2–16)	2.5 (1–5)	0.03
Pain	23.7 (20–27)	24.1 (16–32)	15.2 (12–19)	0.03	31.4 (19–43)	12.3 (8–17)	< 0.001
Single items
Dyspnoea	15.5 (12–19)	22.4 (15–30)	15.6 (12–19)	0.08	32.3 (22–43)	15.8 (11–20)	< 0.01
Insomnia	27.9 (24–32)	21.2 (12–30)	18.7 (14–24)	0.61	27.5 (16–39)	20.9 (15–27)	0.27
Appetite loss	12.9 (10–16)	31.3 (21–42)	14.9 (10–20)	< 0.01	17.6 (9–26)	6.5 (3–10)	0.01
Constipation	8.5 (6–11)	10.9 (5–17)	9.52 (6–13)	0.68	14.7 (5–25)	8.7 (5–12)	0.17
Diarrhoea	4.3 (3–6)	5.44 (1–10)	5.11 (2–8)	0.87	6.9 (2–15)	5.2 (2–8)	0.61
Financial loss	13.5 (10–17)	24.5 (15–34)	14.0 (9–19)	0.03	17.6 (7–28)	7.0 (3–11)	0.03

Abbreviations: RT radiotherapy, CI confidence interval

Scores range from 0 to 100. Higher scores in the function domains and global quality of life indicate better function, whereas higher scores in symptom domains indicate increased symptom burden