Fig. 5.

Effect of compounds E-243, IIIa–IIIc on BV-2 cell viability. BV-2 cells were incubated for 24 h in the presence of increasing concentrations of the compounds tested (0.78 × 10^–6 – 50 × 10^–6 M). Cell viability was measured by an MTS assay. Each point represents the mean ± SEM of three independent experiments, each of which consisted of three replicates per treatment group. Data are presented as a percentage of control cells treated with 0.1% DMSO (Veh). Data were analyzed by one-way ANOVA followed by the Dunnett’s multiple comparison test (α  $=$ 0.05). Data indicated with *p $<$ 0.05; ***p $<$ 0.001 (versus vehicle-treated cells) reflect statistically significant differences between the control and experimental groups