Table 2.

Pharmacological activity of compounds E243 and IIIa-IIIc

^a[³H] N^α-Methylhistamine binding assay performed with cell membrane preparation of CHO-K1 cells stably expressing the human H₃ receptor; mean value of two independent experiments ± SEM

^b[³H]Pyrilamine binding assay performed with cell membrane preparation of CHO-K1 cells stably expressing the human histamine H₁ receptor; mean value of at least triplicate independent experiments ± SEM or within the 95% confidence interval (CI)

^c[³H]Histamine binding assay performed with cell membrane preparation of Sf9 cells transiently expressing the human histamine H₄ receptor, co-expressed with G protein Gα_i2 and Gß_1γ2 subunits; mean value of at least triplicate independent experiments within the 95% confidence interval (CI)

^d[³H] N^α-Methylhistamine binding assay performed with cell membrane preparation of HEK293 cells stably expressing the human H₃ receptor; mean value of triplicate independent experiments; data from Bajda et al. [35]

^ent not tested