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IC50 values determined by fitting a sigmoidal dose–response curve to the data using Graph Pad Prism
| Compound | IC50 a ± SD (μM) |
|---|---|
| E243 | 53.46 ± 5.56 |
| IIIa | 21.19 ± 1.98 |
| IIIb | 26.69 ± 3.48 |
| IIIc | 11.34 ± 3.26 |
aThe mean value of IC50 from the MTS assay in BV-2 cells at the 24 h of exposure. The IC50 value of each compound was defined as the concentration (μM) that caused 50% inhibition of cell viability in BV-2 cells compared to vehicle-treated cells
