Table 2.
Multivariate logistic regression analysis of potential risk factors for pertussis between 2009 and 2018
| Odds ratio (95% CI) | ||
|---|---|---|
| Crude | Adjusteda | |
| Respiratory conditions within 12 months prior to index date | ||
| Asthma | 9.28 (7.96–10.82) | 2.08 (1.68–2.58) |
| COPD | 8.77 (6.72–11.44) | 2.32 (1.59–3.39) |
| Pertussis-like clinical conditions within 30 days prior to index date | ||
| Acute bronchitis | 23.75 (20.14–28.00) | 4.86 (3.84–6.14) |
| Allergic rhinitis | 19.33 (16.34–22.86) | 1.71 (1.32–2.21) |
| Pneumonia | 72.58 (48.06–109.63) | 8.28 (5.10–13.44) |
| URTI | 15.28 (13.08–17.85) | 2.90 (2.30–3.67) |
| Other medical conditions within 12 months prior to index date | ||
| Cancer | 3.39 (2.67–4.31) | 1.68 (1.23–2.31) |
| Cardiovascular disease | 4.02 (3.50–4.63) | 1.62 (1.31–2.00) |
| Cerebrovascular disease | 2.56 (2.08–3.16) | 1.12 (0.84–1.48) |
| Diabetes | 2.80 (2.42–3.25) | 0.92 (0.74–1.15) |
| GERD | 7.17 (6.26–8.22) | 2.67 (2.23–3.19) |
| Hyperlipidemia | 3.88 (3.34–4.43) | 1.43 (1.16–1.77) |
| Hypertension | 2.71 (2.38–3.10) | 0.96 (0.79–1.19) |
| Autoimmune disease | 4.57 (4.00–5.23) | 1.50 (1.25–1.79) |
| Liver disease | 3.60 (3.11–4.17) | 1.07 (0.87–1.32) |
| Renal disease | 3.32 (2.61–4.22) | 1.56 (1.12–2.16) |
| Co-medications within 12 months prior to index date | ||
| Immunosuppressive drugs (excluding corticosteroids) | 5.74 (3.49–9.44) | 1.89 (0.95–3.76) |
1004 pertussis cases and 9710 matched controls were included in this analysis
CI confidence interval, COPD chronic obstructive pulmonary disease, GERD gastroesophageal reflux disease, URTI upper respiratory tract infection
Significant values (p < 0.05) are shown in bold
aThe multivariate model adjusted for each of the characteristics, including comorbidities, co-medications assessed within 12 months prior to index date and pertussis-like clinical conditions assessed within 30 days of index date