Table 2. Analysis results for the association between cumulative alcohol consumption and EAA at examination years 15 and 20.

	Year 15		Year 20		GEE
	β [95% CI]	P	β [95% CI]	P	β [95% CI]	P
Beer Years
IEAA	–0.04 [–0.17, 0.09]	0.526	–0.08 [–0.19, 0.02]	0.129	–0.07 [–0.17, 0.04]	0.216
EEAA	0.01 [–0.15, 0.16]	0.909	–0.03 [–0.15, 0.09]	0.600	–0.02 [–0.13, 0.09]	0.758
PAA	0.11 [–0.07, 0.29]	0.241	0.05 [–0.10, 0.19]	0.516	0.07 [–0.05, 0.19]	0.275
GAA	0.12 [0.01, 0.22]	0.035	0.15 [0.06, 0.24]	0.001	0.13 [–0.01, 0.27]	0.075
Liquor Years
IEAA	0.12 [–0.13, 0.38]	0.344	–0.11 [–0.32, 0.10]	0.306	–0.02 [–0.22, 0.18]	0.832
EEAA	–0.13 [–0.44, 0.17]	0.396	–0.08 [–0.30, 0.15]	0.512	–0.11 [–0.29, 0.07]	0.247
PAA	0.19 [–0.16, 0.55]	0.291	0.13 [–0.15, 0.41]	0.372	0.14 [–0.13, 0.41]	0.313
GAA	0.32 [0.11, 0.54]	0.003	0.33 [0.16, 0.50]	<0.001	0.31 [0.11, 0.51]	0.002
Wine Years
IEAA	0.17 [–0.13, 0.48]	0.265	0.03 [–0.19, 0.24]	0.813	0.08 [–0.08, 0.23]	0.328
EEAA	–0.01 [–0.38, 0.35]	0.952	–0.06 [–0.29, 0.17]	0.610	–0.05 [–0.26, 0.16]	0.645
PAA	0.18 [–0.24, 0.61]	0.405	0.02 [–0.27, 0.31]	0.892	0.07 [–0.22, 0.35]	0.649
GAA	0.08 [–0.18, 0.33]	0.546	0.11 [–0.07, 0.28]	0.228	0.09 [–0.11, 0.30]	0.359
Total Alcohol Years
IEAA	0.01 [–0.08, 0.10]	0.820	–0.05 [–0.12, 0.02]	0.182	–0.03 [–0.10, 0.04]	0.436
EEAA	–0.01 [–0.13, 0.10]	0.806	–0.03 [–0.11, 0.05]	0.438	–0.03 [–0.10, 0.05]	0.455
PAA	0.10 [–0.03, 0.23]	0.138	0.04 [–0.06, 0.14]	0.414	0.06 [–0.03, 0.15]	0.202
GAA	0.11 [0.03, 0.19]	0.005	0.13 [0.07, 0.19]	<0.001	0.12 [0.02, 0.21]	0.013

Results are adjusted for chronological age, sex, race, center, education, pack years of smoking, BMI, and physical activity. Beta coefficients represent the gain in EAA for each additional 5 alcohol years. Abbreviations: IEAA: intrinsic epigenetic age acceleration; EEAA: extrinsic epigenetic age acceleration; PAA: PhenoAge acceleration; GAA: GrimAge acceleration.