Table 3. Analysis results for the association between recent binge drinking and EAA at examination years 15 and 20.

	Year 15		Year 20		GEE
	β [95% CI]	P	β [95% CI]	P	β [95% CI]	P
Recent Binge
IEAA	–0.33 [–0.97, 0.32]	0.320	–0.30 [–0.99, 0.38]	0.386	–0.32 [–0.80, 0.16]	0.195
EEAA	–0.31 [–1.08, 0.46]	0.429	–0.60 [–1.36, 0.15]	0.115	–0.45 [–1.02, 0.13]	0.126
PAA	0.22 [–0.67, 1.12]	0.624	0.27 [–0.65, 1.20]	0.563	0.24 [–0.44, 0.93]	0.486
GAA	1.22 [0.69, 1.76]	<0.001	1.55 [0.99, 2.11]	<0.001	1.38 [0.92, 1.83]	<0.001
Recent Binge Quantity
IEAA	–0.04 [–0.12, 0.05]	0.389	0.00 [–0.10, 0.10]	0.983	–0.02 [–0.12, 0.08]	0.654
EEAA	–0.06 [–0.16, 0.04]	0.244	0.03 [–0.08, 0.15]	0.575	–0.02 [–0.10, 0.06]	0.635
PAA	–0.04 [–0.16, 0.07]	0.475	0.14 [0.00, 0.28]	0.055	0.03 [–0.07, 0.13]	0.579
GAA	0.11 [0.04, 0.18]	0.002	0.21 [0.12, 0.29]	<0.001	0.15 [0.07, 0.23]	<0.001

Results are adjusted for chronological age, sex, race, center, education, pack years of smoking, BMI, and physical activity. Beta coefficients for recent binge represents the gain in EAA for participants who binge drank in the past 30 days and the beta coefficients for recent binge quantity represents the gain in EAA for each additional day of binge drinking in the past 30 days. Abbreviations: IEAA: intrinsic epigenetic age acceleration; EEAA: extrinsic epigenetic age acceleration; PAA: PhenoAge acceleration; GAA: GrimAge acceleration.