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. 2023 Feb 13;14:802. doi: 10.1038/s41467-023-36519-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Immunohistochemistry for Mbp (green), Iba1 (white), Cd74 (red), and DAPI (blue) in the DG of WT at 6-months and App^NL-G-F mice at 1, 3, and 6-months of age. White, Cd74+oligodendrocyte; Black, Cd74+microglia. b Quantification of Cd74/Mbp-positive cells in WT and App^NL-G-F mice at 1, 3, and 6-months of age. All data are expressed as mean ± SEM, n = 6. **p < 0.01, two-sided Student’s t-test. c The frequencies of Cd74+ and Olig2+ were determined by FACS analysis. Representative FACS plots are shown. d Bar graph illustrating the results of the quantitative FACS analysis of Cd74-positive subsets of the Olig2-positive population. e Electron micrographs of axons in the DG from 6-month-old WT and App^NL-G-F mice. f Percentage of unmyelinated axons in the DG of 6-month-old WT and App^NL-G-F mice. All data are expressed as mean ± SEM, n = 3. **p < 0.01, two-sided Student’s t-test. g Percentage of small-caliber axons in DG regions from 6-month-old WT and AD mice. All data are expressed as mean ± SEM, n = 3. **p < 0.01, two-sided Student’s t-test. h Scatter plot of g-ratio values in DG regions from 6-month-old WT and App^NL-G-F mice. i Distribution of the axon caliber of DG regions from 6-month-old WT and App^NL-G-F mice. j g-ratio of 6-month-old WT and AD mice according to axon diameter. All data are expressed as mean ± SEM, n = 3. **p < 0.01, two-sided Student’s t-test. k Immunohistochemistry for Mbp (green), Cd74 (red), and DAPI (blue) in primary oligodendrocytes with mutAPP treatment. l Percentage of Cd74/Mbp-positive cells. Data are expressed as mean ± SEM, n = 4. **p < 0.01, two-sided Student’s t-test. m Branch lengths of mutAPP primary oligodendrocytes by branch length. Data are expressed as mean ± SEM, n = 3. *p < 0.05, two-sided Student’s t-test. n Number of oligodendrocyte branches. Data are expressed as mean ± SEM, n = 3. **p < 0.01, two-sided Student’s t-test. Source data and p-values in b, d, f–j, and l–n are provided as a Source Data file.