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. 2023 Feb 13;14:797. doi: 10.1038/s41467-023-36296-4

Fig. 7. Chemotherapy reduces expression of inhibitory checkpoint molecules and ligand-receptor interactions in PDAC.

Fig. 7

A Heatmap displaying an overview of all inferred LRIs between displayed cell types (cancer cells, MDSCs, DCs, C1QC + TAMs, SPP1 + TAMs, iCAFs, myCAFs, CD8 + T cells, CD4 + T cells). Left: untreated samples, right: treated samples. CAF cancer-associated fibroblast, DC dendritic cell, iCAF inflammatory CAF, LRI ligand-receptor interaction, MDSC myeloid-derived suppressor cell, myCAF myofibroblastic CAF, TAM tumor-associated macrophage. B Heatmap displaying the fold change between the number of inferred LRIs in naïve and treated samples for each pair of cell types. Red indicates more inferred LRIs in naïve samples and blue indicates more inferred LRIs in treated samples. C Dot plot of CellphoneDB output (see Methods) for recruitment-associated LRIs between iCAFs/myCAFs and SPP1 + /C1QC + TAMs comparing untreated and treated samples. D Differential gene expression of checkpoint molecules in CD8 + T cells between treated and untreated samples. E Dot plot of CellphoneDB output (see Methods) for checkpoint molecule LRIs between CD8 + T cells, SPP1 + or C1QC + TAMs, and cancer cells comparing untreated and treated samples.