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Calculated by fetal/average maternal plasma ratio (%) after a single intravenous ( i.v.) injection either as monotherapy or in combination with: cimetidine (CIM, 11 mg/kg), digoxin (DIG, 0.03 mg/kg), lamotrigine (LTG, 6 mg/kg), paracetamol (PARA, 15 mg/kg) or valproate (VPA, 30 mg/kg). Bars are means±SD. Note each point is an individual animal (n=4–26). ***p<0.001, ****p<0.0001.
