Figure 5. Counts (DPM/μl) in plasma of dams and their fetuses at E19.

(A) A single intravenous ( i.v.) injection of 0.15 mg/kg olanzapine with a radioactive tracer ([ ³H]olanzapine) to each dam and (B) counts (DPM/μl) in plasma after 4 daily intraperitoneal ( i.p.) injections of 0.15mg/kg olanzapine followed by olanzapine with a radioactive tracer ([ ³H]olanzapine) i.v. on the 5 ^th day. (C) Placental transfer as calculated by fetal/average maternal plasma ratio (%) using results from A and B. Bars are means±SD. Note dam values are serial plasma samples taken between 30–160 min post maternal injection from one or two individual dams, fetal values and ratios are from individual animals (n=10–25). *p<0.05.