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(A) Brain cortex, (B) brainstem and (C) cerebrospinal fluid (CSF) after a single intravenous ( i.v.) injection either as monotherapy or in combination with: cimetidine (11 mg/kg), digoxin (DIG, 0.03 mg/kg), lamotrigine (LTG, 6 mg/kg), lithium (Li, 3.2 mg/kg), paracetamol (PARA, 15 mg/kg) or valproate (VPA, 30 mg/kg). Bars are means±SD. Note each point is an individual animal (n=4–21). *p<0.05, ****p<0.0001.
