Fig. 8.

IR780@PLGA nanoparticle-mediated aSDT for myositis. (A) Schematic illustration of the sonotherapeutic IR780@PLGA nanoparticles for combating multidrug-resistant bacterial infections. (B) TEM image of IR780@PLGA nanoparticles. (C) Time-dependent ¹O₂ generation of IR780@PLGA nanoparticles with US irradiation (1 ​MHz, 2.0 ​W/cm²). (D) Fluorescent images of DCF-stained ¹O₂ generation by bacteria and SEM images of the bacterial biofilm in different groups. (E) Time-lapse NIR fluorescence images of MRSA-infected mice in vivo after injection of IR780@PLGA nanoparticles. (F) Averaged ex vivo NIR fluorescence intensities. (G) Representative US and histological images of MRSA-infected mice in different groups [61]. Copyright@2022, Huang B et al.