Table 1.
Ncrnas impact on ion channel and neuronal excitability following nerve injury.
| ncRNAs/Biogenesis regulators | Species | Model | Regulation | Location | Target | Physiological functions [1] | Reference |
|---|---|---|---|---|---|---|---|
| Dicer | Mouse | N/A | Nav1.8 Cre Dicer conditional knockout | Nociceptive neurons | Nav1.8 | Inflammatory pain ↓ [2], | (J. Zhao et al., 2010) |
| miR-182 | Rat | Spared nerve injury (SNI) | ↓ | DRG | Nav1.7 (SCN9A) | Nav1.7 ↑ [3], Mechanical hypersensitivity ↑ |
(W. Cai et al., 2018) |
| miR-30b | Rat | SNI | ↓ | DRG | Nav1.7 (SCN9A) | Nav1.7 ↑, Mechanical hypersensitivity ↑ |
(Shao et al., 2016) |
| miR-30b | Rat | Spinal nerve ligation (SNL) | ↓ | DRG, Spinal cord |
Nav1.3 (SCN3A) | Nav1.3 ↑, Mechanical and thermal hypersensitivity ↑ |
(Su et al., 2017) |
| miR-183 | Rat | SNL | ↓ | DRG | Nav1.3 (SCN3A) BDNF |
Nav1.3 ↑, BDNF ↑, Mechanical hypersensitivity ↑ |
(Lin et al., 2014) |
| miR-96 | Rat | Chronic constriction injury (CCI) | ↓ | DRG | Nav1.3 (SCN3A) | Nav1.3 ↑, Mechanical and thermal hypersensitivity ↑ |
(H.-P. Chen et al., 2014) |
| miR-384 | Rat | CCI | ↓ | DRG, Spinal cord |
Nav1.3 (SCN3A) | Nav1.3 ↑, Mechanical and thermal hypersensitivity ↑, IL-6, IL-1B, COX-2, and TNF-a ↑, Neuroinflammation ↑ |
(Ye et al., 2020) |
| miR-7a | Rat | SNL | ↓ | DRG | SCN2B | SCN2B ↑, Mechanical and thermal hypersensitivity ↑ |
(Sakai et al., 2013) |
| miR-34a | Rat | CCI | ↓ | DRG | SCN2B VAMP-2 |
VAMP-2 ↑, Mechanical hypersensitivity ↑ |
(Brandenburger et al., 2019) |
| miR-7a | Rat | SNL | ↓ | DRG | NEFL/STAT3 axis | NEFL ↑, STAT3 phosphorylation ↑, Mechanical and thermal hypersensitivity ↑ |
(Yang et al., 2019) |
| miR-17/92 cluster (miR-17, miR-18a, miR-19a, miR-20a, and miR-82a) | Rat | SNL | ↑ | DRG | Voltage-gated potassium channels (KCNA1, KCNA3, KCNA4, KCNA5) |
Voltage-gated potassium channels ↓, Outward potassium currents ↓, Mechanical hypersensitivity ↑ |
(Sakai et al., 2017) |
| miR-103 | Rat | N/A | miR-103 mimic introduction | Spinal cord | Cav1.2 | Cav1.2 LTC subunits ↓, Mechanical and cold hypersensitivity ↓ |
(Favereaux et al., 2011) |
| Let-7b | Mouse | N/A | ↑ in neuronal exosomes by neuronal activation | Exosome released by DRG neurons | TLR7 TRPA1 |
Inward currents and action potentials ↑, Spontaneous pain ↑ |
(Park et al., 2014, p. 7) |
| KCNA2-AS | Rat/Mouse | SNL | ↑ | DRG | Kcna2 | Kcna2 ↓, Neuronal resting membrane potential ↑, Mechanical and cold hypersensitivity ↑ |
(X. Zhao et al., 2013) (Long et al., 2017) |
[1] Details in manuscript. [2] ↓ Downregulate. [3] ↑ Upregulate.