Table 3.

Ncrnas in nerve survival and regeneration following nerve injury.

ncRNAs/Biogenesis regulators	Species	Model	Regulation	Location	Target	Physiological functions	Reference
Dicer	Mouse	Sciatic nerve crush	CAG-CreER Dicer conditional knockout	Sciatic nerve, DRG neurons	N/A	Mechanical sensitivity ↓, Nerve anatomical, physiological, and functional recovery ↓, Axon regeneration ↓	(D. Wu et al., 2012)
RISC, P body	Mouse	Sciatic nerve crush	↑	Sciatic nerve, DRG neurons	N/A	RISC components (FMRP, Ago2 and P-100) ↑, P-body components (Dcp1 and GWB IC-6) ↑, (Dcp2 and Ro2) ↓	(D. Wu et al., 2011)
miR-138	Mouse	Sciatic nerve crush	↓	DRG neurons	SIRT1	SIRT1 ↑, miR-138 and SIRT1 are part of a mutual negative feedback loop, Neurite extension and outgrowth ↑, Axon regeneration in vivo ↑	(C.-M. Liu et al., 2013)
miR-206	Rat	CCI	↓	DRG neurons	BDNF/MEK/ERK axis	BDNF ↑, MEK/ERK pathway activation ↑, Mechanical and thermal hypersensitivity ↑	(Sun et al., 2015)
miR-133b	Zebrafish	Spinal cord transection	↑	The nucleus of the medial longitudinal fascicle (NMLF)	RhoA	RhoA ↓, Regeneration of axons from NMLF ↑, Superior reticular formation ↑, Intermediate reticular formation ↑	(Ym et al., 2011)
miR-34c	Mouse	STZ- induced diabetes	↑	TG neurons	Atg4B	Atg4B, LC3-II ↓, Autophagy ↓, Wound healing ↓, Corneal nerve regeneration ↓	(J. Hu et al., 2019)
miR-9	Mouse	Sciatic nerve crush	↓	DRG neurons	FoxP1	FoxP1 ↑, Neurite extension and outgrowth ↑, Axon regeneration in vivo ↑	(J. Jiang et al., 2017)
miR-132	Mouse	N/A	Enriched in DRG neurons	DRG neurons	RASA1	RASA1 ↓, Neurite extension and outgrowth ↑	(Hancock et al., 2014)
miR-9 Let-7	Rat	Sciatic nerve crush	Let-7 ↓, miR-9 ↓	Sciatic nerve (Schwann cells), DRG neurons	Ntn1, DCC	Ntn1, Dcc production and secretion in Schwann cells ↑, Schwann cell migration ↑, Neurite extension and outgrowth ↑	(X. Wang et al., 2019)